OZ-P-065: IS O3 OZONE INHALETED Carcinogen?
Siegfried Schulz.
Veterinary Services, Philipp-University of Marburg / L Germany.
Ozone as a major constituent of smog Photochemical Has Been Suspected as a Risk Factor for the Development of lung cancer. The inhalation of ozone is Strongly Excluded for Therapeutic Strategies in the use of medical ozone, ozone inhalation But can not always be prevented in outdoor (atmosphere) and indoor (ozone user and patients) situations.
Whether ozone has Has Been Repeatedly carcinogen Potential Examined in isolated cell systems or in experimental animals. Mice seem to be the MOST sensitive Indicators for lung tumor carcinogenesis in comparison to rats. With a new design of Inhaled ozone (ultra short x high ppm) Compared our results we, from NMRI-mice, With That Calculated dosages of other authors and discussed This carcingenesis the steps of (inhibition-promotion-progression).
Ozone is not a primary lung carcinogen Compared to Urethan (neumotropic carcinogen). Ozone Enhances the promotion of lung tumors Otherwise Initiated (pro-carcinogenesis) And Also inhibits the promotion (Anticarcinogenesis) Probably by direct cytotoxic effects.
Inhaled ozone has a mitogenic activity on lung cells (Typ II pneumocytes cell hyperplasia) and by Malthus it Enhances the Risk for initiation of lung tumors (adenonas) Caused by Carcinogenic chemicals neumotropic.
There Was no Evidence for ozone carcinogenesis in NMRI-mice without a Carcinogenic drug.
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